Follow-Up: I started taking St. John's Wort after discontinuing Zoloft 2 weeks ago. I took Zoloft for PMS. Zoloft had too many side effects not for me, so I am trying this, although St. John's isn't doing the same job, I am afraid I'm not giving it much of a chance. From what I am reading, it will take at least a month to start working. I am trying to hang in there, my bouts with mood swings, irritability, etc. are getting the best of me and my dear family. I would love any feedback on taking St. John's Wort due to PMS.