Follow-Up: I would really like to hear from someone whose experiences are more like mine. I am 47, female, diagnosed with MS in 1995. My primary problem is fatigue and inability to "stay on tasks." I work 30 hours a week. I've been on Amantidine, Ritalin, Zoloft (still am), and now my neurology nurse practitioner is recommending Provigil. First of all, is it affordable? I belong to an HMO that will probably charge me over $100 a month for it. That's too much for us to spend. Is it helpful over a long period of time for M.S. fatigue? I look forward to some advice.